Acesso livre
Acesso livre

Estudos Randomizados

Estudo randomizado | Segurança e eficácia da terceira dose de vacina da Pfizer contra Covid-19 durante a onda Delta.

25 Mar, 2022 | 14:56h

Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine – New England Journal of Medicine

 

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[Comunicado de imprensa – ainda não publicado] Estudo randomizado | Abordagem minimamente invasiva para histerectomia no câncer de colo do útero está associada à pior sobrevida livre de doença do que a cirurgia aberta.

25 Mar, 2022 | 14:49h

Minimally Invasive Approach to Hysterectomy in Cervical Cancer Associated with Poorer Disease-Free Survival Than Open Surgery – Society of Gynecologic Oncology

Estudo randomizado | Efeito de um programa de atividade física sobre o declínio da mobilidade funcional em idosos.

23 Mar, 2022 | 12:05h

Effect of a physical activity and behaviour maintenance programme on functional mobility decline in older adults: the REACT (Retirement in Action) randomised controlled trial – The Lancet Public Health

Ver também: Cost-effectiveness of a physical activity and behaviour maintenance programme on functional mobility decline in older adults: an economic evaluation of the REACT (Retirement in Action) trial – The Lancet Public Health

Comunicado de imprensa: Landmark study demonstrates long-term positive impacts and cost effectiveness of tailored group exercise for over-65s with mobility limitations

Comentário convidado: Considerations for maintaining functional mobility in older populations – The Lancet Public Health

Estudo randomizado | Levotiroxina não é benéfica para mulheres eutireóideas com anticorpo positivo para peroxidase tireóidea e perda gestacional recorrente.

23 Mar, 2022 | 11:39h

Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Diabetes & Endocrinology (link para o resumo – $ para o texto completo)

Comentário: Levothyroxine No Boon for Birth Rates in Women With Possible Thyroid Disorder – MedPage Today (necessário cadastro gratuito)

Estudo randomizado de fase 2 | Terapia celular derivada de cardiosfera intravenosa repetida na distrofia muscular de Duchenne em estágio tardio.

23 Mar, 2022 | 11:25h

Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy (HOPE-2): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial – The Lancet

Comentário: Cellular therapy improves signs and symptoms of Duchenne muscular dystrophy – University of California – Davis Health

 

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Estudo randomizado | Eficácia e aceitação de terapias dietéticas na síndrome do intestino irritável sem constipação: um estudo randomizado comparando aconselhamento dietético tradicional, dietas de baixo FODMAP e dietas sem glúten.

22 Mar, 2022 | 11:46h

Efficacy and Acceptability of Dietary Therapies in Non-Constipated Irritable Bowel Syndrome: A Randomized Trial of Traditional Dietary Advice, the Low FODMAP Diet and the Gluten-Free Diet – Clinical Gastroenterology and Hepatology

Comentário: Traditional Dietary Advice Optimal as an Irritable Bowel Syndrome Therapy – HCPLivre

Conteúdos relacionados:

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

Estudo randomizado | Modalidade de exames de imagem (TC vs. RM) e frequência (7 exames em 60 meses vs. 3 exames em 36 meses) na vigilância do seminoma testicular maligno estágio I.

22 Mar, 2022 | 11:38h

Imaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST) – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

Estudo randomizado | Melhora sintomática precoce após terapia com ustequinumabe em pacientes com colite ulcerativa.

22 Mar, 2022 | 11:26h

Early symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis: 16-week data from the UNIFI trial – Clinical Gastroenterology and Hepatology (link para o resumo – $ para o texto completo)

Estudo randomizado | Poractante alfa nebulizado em bebês prematuros com síndrome da angústia respiratória.

22 Mar, 2022 | 11:25h

A Randomized, Controlled Trial to Investigate the Efficacy of Nebulized Poractant Alfa in Premature Babies with Respiratory Distress Syndrome – The Journal of Pediatrics

Comentário: Should we give up on nebulised surfactant? – Neonatal Research

 

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Estudo randomizado | Suplementação de flavonóis de cacau mostrou-se promissora na prevenção de eventos cardiovasculares.

21 Mar, 2022 | 16:29h

Effect of cocoa flavanol supplementation for prevention of cardiovascular disease events: The COSMOS randomized clinical trial – American Journal of Clinical Nutrition

Comentário: New trial finds signs of preventive cardiovascular effects for cocoa flavanols – Brigham and Women’s Hospital

 

Comentário no Twitter (fio – clique para saber mais)

 

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