Estudos Randomizados
Estudo randomizado | Litotripsia por onda de choque comparada com tratamento ureteroscópico para adultos com cálculos ureterais.
1 Abr, 2022 | 13:15hDownload: Full Report
Estudo randomizado | Tratamento combinado de amisulprida e olanzapina vs. cada um em monoterapia para pacientes esquizofrênicos e agudamente doentes.
1 Abr, 2022 | 13:07hAmisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia in Germany (COMBINE): a double-blind randomised controlled trial – The Lancet Psychiatry (link para o resumo – $ para o texto completo)
Comentário no Twitter
RCT: At 8 weeks, PANSS total score improved more with amisulpride + olanzapine (−29·6) than with olanzapine + placebo (−24·1, p=0·049, d=0·396), but not vs. amisulpride + placebo (−25·2, p=0·095, d=0·29) in acutely ill patients with schizophrenia https://t.co/Se75PJ3a0N
— PfOL (@psychopharmacol) March 18, 2022
Estudo randomizado | Efeito do tacrolimo vs. ciclofosfamida intravenosa na resposta parcial ou completa de pacientes com nefrite lúpica.
1 Abr, 2022 | 12:17h
Comentário no Twitter
In this RCT, oral tacrolimus was noninferior to intravenous cyclophosphamide for initial therapy of active lupus nephritis, with a more favorable safety profile. https://t.co/scz7lahVRU
— JAMA Network Open (@JAMANetworkOpen) March 30, 2022
Estudo randomizado por cluster | Uma intervenção domiciliar de substituição do sal é custo-efetiva para a prevenção de AVC e melhorar a qualidade de vida.
29 Mar, 2022 | 15:17hComentário: ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving – HealthDay
Conteúdos relacionados:
Former CDC director: Low sodium salt could save millions of lives – CNN
Is salt good for you after all? The evidence says no.
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
New WHO benchmarks help countries reduce salt intake and save lives.
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels
Estudo randomizado | Comparação de 3 diferentes técnicas cirúrgicas minimamente invasivas para estenose de coluna lombar.
29 Mar, 2022 | 14:49h
Comentário no Twitter
A pragmatic randomized clinical trial of patients treated surgically for lumbar spinal stenosis found no difference in the clinical results from three minimally invasive decompression techniques at 2 years follow up. https://t.co/6b5J5RzKpF
— JAMA Network Open (@JAMANetworkOpen) March 28, 2022
Estudo transversal randomizado | Efeitos da restrição de sono experimental sobre a ingestão e o gasto de energia e a obesidade visceral.
29 Mar, 2022 | 14:42hEffects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity – Journal of the American College of Cardiology (link para o resumo – $ para o texto completo)
Comentário: Lack of sleep increases unhealthy abdominal fat, study finds – Mayo Clinic
Conteúdo relacionado: RCT: Advising overweight patients to increase sleep duration may reduce caloric intake.
Estudo randomizado | Efeito da quimioterapia de indução com paclitaxel, cisplatina e capecitabina vs. cisplatina e fluorouracil na sobrevida livre de recorrência para pacientes com carcinoma nasofaríngeo estágios IVA a IVB.
29 Mar, 2022 | 13:49hEffect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial – JAMA Oncology (link para o resumo – $ para o texto completo)
Comentário: Triplet Induction Regimen Bests Doublet for Nasopharyngeal Carcinoma — Three drugs reduced risk of disease failure, but longer follow-up needed to assess OS – MedPage Today (necessário cadastro gratuito)
Comentário no Twitter
Phase 3 randomized trial of paitents with stage IVA to IVB nasopharyngeal carcinoma shows that induction chemotherapy w 2 cycles of paclitaxel/cisplatin/capecitabine improved failure-free survival vs. cisplatin/5-FU before concurrent chemoradiation. https://t.co/YYEvFsTxgd pic.twitter.com/7qbSXLWCE1
— JAMA Oncology (@JAMAOnc) March 24, 2022
Estudo randomizado | Nitroglicerina não evita a oclusão radial após acesso transradial no cateterismo em laboratório.
29 Mar, 2022 | 13:42hRandomized Clinical Trial on Prevention of Radial Occlusion After Transradial Access Using Nitroglycerin: PATENS Trial – JACC: Cardiovascular Interventions (link para o resumo – $ para o texto completo)
Comentário: Nitroglycerin Given Early or Late Fails to Prevent Radial Artery Occlusion: PATENS – TCTMD
Estudo randomizado | Entre prematuros com idade gestacional menor que 30 semanas e entubados por pelo menos 7 e nascidos de 14 a 28 dias, hidrocortisona não melhorou a sobrevida sem displasia broncopulmonar.
25 Mar, 2022 | 15:03hHydrocortisone to Improve Survival without Bronchopulmonary Dysplasia – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Ver também: Visual Abstract
Conteúdos relacionados:
State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.
ERS Guideline on Long-term Management of Children with Bronchopulmonary Dysplasia
Comentário no Twitter
In this trial involving preterm infants, there was little difference in survival without bronchopulmonary dysplasia or in the occurrence of neurodevelopmental impairment with hydrocortisone as compared with placebo. https://t.co/wzGQ1gohjA pic.twitter.com/yfrIaG3JLv
— NEJM (@NEJM) March 23, 2022
Estudo randomizado | Posição prona em pacientes não intubados não melhorou os desfechos em pacientes com hipoxemia moderada relacionada à Covid-19.
25 Mar, 2022 | 14:58hEditorial: Awake prone positioning for patients with covid-19
Comunicado de imprensa: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ