Acesso livre
Acesso livre

Destaques

Estudo randomizado | Dapagliflozina não trouxe melhora significativa para o controle glicêmico de crianças e jovens adultos com diabetes tipo 2.

14 Abr, 2022 | 17:42h

Efficacy and safety of dapagliflozin in children and young adults with type 2 diabetes: a prospective, multicentre, randomised, parallel group, phase 3 study – The Lancet Diabetes & Endocrinology (link para o resumo – $ para o texto completo)

Revisão | Menos é mais: deprescrição de medicamentos em idosos com doença renal.

14 Abr, 2022 | 17:41h

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Conteúdos relacionados:

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review.

AGA clinical practice update on de-prescribing of proton pump inhibitors.

Development of a metric to detect and decrease low-value prescribing in older adults.

Cluster Randomized Clinical Trial: An electronic decision support system for deprescribing in hospitalized older adults was safe and led to improvements in deprescribing but did not reduce adverse drug events.

Systematic Review: Quantifying anticholinergic burden and sedative load in older adults with polypharmacy.

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines.

Systematic review: Prescribing practices, patterns, and potential harms in patients receiving palliative care – “many patients receiving palliative care receive multiple medications closer to the time of death”.

A narrative review of evidence to guide deprescribing among older adults.

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens.

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt internationa

Eliminating Medication Overload: A National Action Plan

Deprescribing in Older Adults With Cardiovascular Disease – Journal of the American College of Cardiology

Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (vários artigos e comentários sobre o tema)

Estudo randomizado | Terapia com realidade virtual automatizada no tratamento da evitação agorafóbica e da angústia em pacientes com psicose.

14 Abr, 2022 | 17:39h

Automated virtual reality therapy to treat agoraphobic avoidance and distress in patients with psychosis (gameChange): a multicentre, parallel-group, single-blind, randomised, controlled trial in England with mediation and moderation analyses – The Lancet Psychiatry

Comunicado de imprensa: Breakthrough success in provision of automated psychological therapy using virtual reality – University of Oxford

 

Comentário do autor no Twitter

 

Estudo randomizado | Vacinação em dose única contra o HPV se mostrou efetiva entre mulheres jovens na África.

14 Abr, 2022 | 17:07h

Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women – NEJM Evidence

Comunicado de imprensa:

Study boosts support for single-dose HPV vaccine regimen – University of Washington

One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer – World Health Organization

Conteúdo relacionado: Three-year follow-up of 2-dose versus 3-dose HPV vaccine

 

Comentário no Twitter (fio – clique para saber mais)

 

Estudo de coorte | Risco de eventos adversos após Covid-19 em crianças e adolescentes dinamarqueses e efetividade da vacina da Pfizer em adolescentes.

14 Abr, 2022 | 17:04h

Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study – The BMJ

M-A | Inibidores de SGLT2 reduzem internações em pacientes com insuficiência cardíaca independentemente da presença de diabetes.

14 Abr, 2022 | 17:02h

Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link para o resumo – $ para o texto completo)

Comunicado de imprensa: SGLT2 inhibitors reduces hospitalization for heart failure regardless of presence of diabetes – American College of Physicians

Diretrizes baseadas em evidência sobre interações medicamentosas entre fármacos anticâncer: uma ferramenta prática e universal para o manejo.

14 Abr, 2022 | 17:01h

Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management – Seminars in Oncology

Diretriz científica AHA | Infecção por SARS-CoV-2 e manifestações cardiovasculares associadas em crianças e jovens adultos.

14 Abr, 2022 | 16:59h

SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association – Circulation

Comunicado de imprensa: Heart issues after COVID-19 uncommon in children and young adults, more research needed – American Heart Association

Comentário: COVID-19 CV Complications in Children Are Rare, Treatable: AHA Statement – TCTMD

Estudo de coorte | Preditores de doença grave em crianças com síndrome inflamatória multissistêmica após infecção pelo SARS-CoV-2.

14 Abr, 2022 | 16:58h

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study – Canadian Medical Association Journal

Comunicado de imprensa: Children older than 5 at higher risk of COVID-19-related multisystem inflammatory syndrome – Canadian Medical Association Journal

Comentário: Older Kids More Vulnerable to MIS-C: Study – HealthDay

Opinião | Alinhando os incentivos para melhorar a excelência diagnóstica.

14 Abr, 2022 | 16:56h

Aligning Incentives for Improving Diagnostic Excellence – JAMA (gratuito por tempo limitado)

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