Destaques
Desinformação: suscetibilidade, disseminação e intervenções para imunizar o público.
11 Mar, 2022 | 15:08hMisinformation: susceptibility, spread, and interventions to immunize the public – Nature Medicine
Ver também: An epidemic of uncertainty: rumors, conspiracy theories and vaccine hesitancy – Nature Medicine
Revisão sistemática | Otimização dos sistemas hospitalares de prescrição eletrônica.
11 Mar, 2022 | 15:07hEstudo randomizado | Terapia comportamental dialética online vs. cuidado usual em pacientes ambulatoriais adultos com ideação suicida (estudo negativo importante).
11 Mar, 2022 | 15:06hEffect of Offering Care Management or Online Dialectical Behavior Therapy Skills Training vs Usual Care on Self-harm Among Adult Outpatients With Suicidal Ideation: A Randomized Clinical Trial – JAMA (link para o resumo – $ para o texto completo)
Comentário: Low-Intensity Care Options Flop for Self-Harm Prevention— In randomized trial, two therapeutic interventions failed to help people with suicidal thoughts – MedPage Today (necessário cadastro gratuito)
Ver também: Visual Abstract
Comentário no Twitter
1/ Let's see if I understand this. You take people who are in so much pain, they want to die. They're likely feeling that no one really cares about them. And you provide "interventions… delivered primarily through electronic health record online messaging." What could go wrong? https://t.co/865QyJp7Dg
— Jonathan Shedler (@JonathanShedler) February 16, 2022
Estudo randomizado | Em crianças com tuberculose não grave e suscetível a medicamentos, o tratamento por 4 meses é não inferior ao tratamento por 6 meses.
10 Mar, 2022 | 15:59hComunicado de imprensa: Treatment length reduced for children with tuberculosis – University College London
Comentário no Twitter
Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy. https://t.co/zkD4URWMru pic.twitter.com/LFR6ZzTKgs
— NEJM (@NEJM) March 9, 2022
Estudo randomizado | Em pacientes com câncer de tireoide de baixo risco, a tireoidectomia sem ablação por radioiodo foi não inferior à tireoidectomia com ablação por radioiodo em 3 anos.
10 Mar, 2022 | 15:57hThyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentário: New research casts doubt on a cornerstone of thyroid cancer treatment – STAT
Comentário no Twitter
In RCT involving patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, a follow-up strategy that did not involve the use of radioiodine was noninferior to the use of radioiodine in the response to treatment at 3 years. https://t.co/RaJL3tdE4T pic.twitter.com/8nIPw50nkg
— NEJM (@NEJM) March 9, 2022
Estudo randomizado | Em pacientes com parada cardíaca refratária fora do hospital, uma estratégia de transporte durante a ressuscitação, ressuscitação cardiopulmonar extracorpórea e estudo invasivo imediato não trouxe melhora significativa para a sobrevida com um desfecho neurológico favorável (OR 1,63; IC 95% 0,93 a 2,85; P = 0,09).
10 Mar, 2022 | 15:55hEffect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link para o resumo – $ para o texto completo)
Comentário: Early Invasive Therapy for Out-of-Hospital Cardiac Arrest – American College of Cardiology
Comentário no Twitter
In this randomized clinical trial, early intra-arrest transport, extracorporeal CPR, and invasive assessment and treatment did not significantly improve survival with neurologically favorable outcome at 180 days compared with standard resuscitation. https://t.co/qSqWSFFpOF pic.twitter.com/SLu0bGHhq8
— JAMA (@JAMA_current) February 22, 2022
M-A | Eficácia comparativa e tolerabilidade de 32 antipsicóticos orais e injetáveis de longa duração para o tratamento de manutenção de adultos com esquizofrenia.
10 Mar, 2022 | 15:53hComparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link para o resumo – $ para o texto completo)
Metanálise de estudos randomizados | Benefícios e prejuízos de anticoagulantes orais diretos e da heparina de baixo peso molecular para a tromboprofilaxia de pacientes submetidos a cirurgia não cardíaca.
10 Mar, 2022 | 15:52h
Comentário no Twitter
Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi
— Kari Tikkinen (@KariTikkinen) March 9, 2022
Perspectiva | Uma vez visto como um tratamento promissor da COVID-19, o plasma convalescente cai em desuso.
10 Mar, 2022 | 15:49hOnce Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA
Perspectiva | O que sabemos sobre o impacto da Covid no cérebro?
10 Mar, 2022 | 15:47hWhat do we know about Covid’s impact on the brain? – The Guardian
Conteúdo relacionado: SARS-CoV-2 is associated with changes in brain structure in UK Biobank.